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Título :	Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid
Creador:	Calderón Guzmán, David
Nivel de acceso:	Open access
Palabras clave :	Aminoácidos - Efectos adversos Aminoácidos - uso terapéutico animales Antioxidantes - Efectos adversos Antioxidantes - uso terapéutico Calcio - metabolismo Corteza Cerebelosa - efectos de drogas Corteza Cerebelosa - metabolismo Cerebelo - efectos de drogas Cerebelo - metabolismo Cerebro - efectos de drogas Cerebro - metabolismo Convulsivantes - Efectos adversos Dopamina - metabolismo Neuronas Dopaminérgicas - efectos de drogas Dopaminérgicas - metabolismo Glutatión - metabolismo Peroxidación de Lípido - efectos de drogas Masculino Bulbo Raquídeo - efectos de drogas Bulbo Raquídeo - metabolismo Enfermedades Neurodegenerativas - inducido químicamente Enfermedades Neurodegenerativas - metabolismo Enfermedades Neurodegenerativas - prevención & control Fármacos Neuroprotectores - Efectos adversos Neuroprotectores - terapeutic use Síndromes de Neurotoxicidad - prevención & control Nitrocompuestos - Efectos adversos Estrés Oxidativo - efectos de drogas Propionatos - Efectos adversos Ratas Consanguíneas F344 Amino Acids - adverse effects Amino Acids - therapeutic use Animals Antioxidants - adverse effects Antioxidants - therapeutic use Calcium - metabolism Cerebellar Cortex - drug effects Cerebellar Cortex - metabolism Cerebellum - drug effects Cerebellum - metabolism Cerebrum - drug effects Cerebrum - metabolism Convulsants - adverse effects Dopamine - metabolism Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Glutathione - metabolism Lipid Peroxidation - drug effects Male Medulla Oblongata - drug effects Medulla Oblongata - metabolism Neurodegenerative Diseases - chemically induced Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - prevention & control Neuroprotective Agents - adverse effects Neuroprotective Agents - therapeutic use Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - prevention & control Nitro Compounds - adverse effects Oxidative Stress - drug effects Propionates - adverse effects Rats, Inbred F344 Cerebrolysin, dopamina, 3-nitropropiónico, Estrés Oxidativo cerebrolysin, dopamine, 3-nitropropionic acid, oxidative stress
Descripción :	The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods. In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased. In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex. The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA. © by Ernestina Hernández García 2016.
Colaborador(es) u otros Autores:	Osnaya Brizuelan Ortíz Herrera M Hernández García E Barragán Mejía G Juárez Olguín H Valenzuela Peraza A Attilus J Labra Ruíz N
Fecha de publicación :	2016
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1515/acph-2016-0027
Fuente:	Acta Pharmaceutica 66(3):443 - 448
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2318
Idioma:	eng
Aparece en las colecciones:	Artículos

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