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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2315| Título : | Effect of allopurinol on damage caused by free radicals to cryptorchid testes |
| Creador: | Vigueras Villaseñor, Rosa María |
| Nivel de acceso: | Open access |
| Palabras clave : | Alopurinol - administración & dosificación - ratas Alopurinol - farmacología - ratas Apoptosis - efectos de drogas - ratas Proliferación de la Célula - efectos de drogas - ratas Criptorquidismo - quimioterapia - ratas Criptorquidismo - etiología - ratas Criptorquidismo - patología - ratas Criptorquidismo - efectos de drogas - ratas Células Epiteliales - efectos de drogas - ratas Células Epiteliales - patología - ratas Depuradores de Radicales Libres - farmacología - ratas Ratas wistar Especies de Oxígeno Reactivo - toxicidad - ratas Testículo - citología - ratas Testículo - efectos de drogas - ratas Testículo - patología - ratas Testículo - cirugía - ratas Allopurinol - administration & dosage -rats Allopurinol - pharmacology -rats Apoptosis - drug effects -rats Cell Proliferation - drug effects -rats Cryptorchidism - drug therapy - rats Cryptorchidism - etiology -rats Cryptorchidism - pathology -rats Epithelial Cells - drug effects -rats Epithelial Cells - pathology -rats Free Radical Scavengers - pharmacology - rats Rats, Wistar Reactive Oxygen Species - toxicity -rats Testis - cytology - rats Testis - drug effects -rats Testis - pathology -rats Testis - surgery -rats Criptorquidia, Radicales libres, Allopurinol, Apoptosis, proliferación, Infertilidad masculina, Testículo Cryptorchidism; Free radicals; Allopurinol; Apoptosis; Proliferation; Male infertility; Testis |
| Descripción : | Cryptorchidism causes apoptosis of germ cells. It has been suggested that the redox regulatory system is involved in this process. The free radicals produced are thought to be generated during the production of uric acid, a reaction catalyzed by xanthine oxidase. This enzyme is inhibited by allopurinol; however, the role of allopurinol in neonate rats with inguinal cryptorchidism has not been assessed yet. Sixty male Wistar rats were used and five groups were formed: a control, a sham, a sham group with allopurinol administration and two groups with surgical unilateral cryptorchidism, which either did not receive, or received, allopurinol. The rats were assessed at 40 days post-partum. Reactive oxygen species concentration and epithelial area were measured and the histopathological, apoptotic and cellular proliferation indexes were determined. We found a decrease in reactive oxygen species, histopathological and apoptotic indexes and an increase in proliferation index and epithelial area in rats with cryptorchidism treated with allopurinol in comparison with rats with untreated cryptorchidism. We suggest that the over-production of reactive oxygen species plays an important role in the damage of the cryptorchid testes. Allopurinol administration decreases reactive oxygen species concentrations as well as the damage to the germ epithelium. © 2008 Elsevier GmbH. All rights reserved. |
| Colaborador(es) u otros Autores: | Molina-Ortiz D Reyes-Torres G del Angel DS Moreno-Mendoza NA Cruz ME Cuevas-Alpuche O Rojas-Castañeda JC |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.acthis.2008.05.004 |
| Fuente: | Acta Histochemica 111(2):127 - 137 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2315 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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