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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2304| Título : | Double blind study of placebo and ribavirin as prophylaxis in cases of contact with varicella in children |
| Creador: | González Saldaña, Napoleón |
| Nivel de acceso: | Open access |
| Palabras clave : | Antivirales - uso terapéutico - niño varicela - prevención & control - niño varicela - terapia - niño Método Doble Ciego Placebos - niño Ribavirina - uso terapéutico - niño Antiviral Agents - therapeutic use - child Chickenpox - prevention & control - child Chickenpox - therapy - child Double-Blind Method - child Placebos - child Ribavirin - therapeutic use - child |
| Descripción : | The aim of this study was to determine whether or not ribavirin provides protection against varicella in those who come in contact with the virus. In a double blind placebo study, ribavirin (20 mg/kg/day, p.o.) or placebo was administered to children who had contact with varicella. Treatment was administered to 61 children (Group 1) within the first 3 days of contact, 45 of them were immunocompetent and 16 were immunodepressed. Treatment was given to 54 children on the 7th day after contact (Group 2); 48 of them were immunocompetent and 6 immunodepressed. In group 1, 11 (50%) of the immunocompetent treated with ribavirin developed chicken pox while 11 (50%) were asymptomatic. For seroconversion, there was no significant difference (p=0.586). In group 2, we did not find varicella in immunocompetent patients receiving ribavirin (0/24), for placebo there were 2 (2/24) cases of varicella. Varicella was not observed in immunodepressed patients in Group 2. A difference was not observed with the administration of ribavirin at day 3 or 7 versus placebo to prevent development of varicella. This study may have implications for the public health efforts in the prophylaxis of chicken pox |
| Colaborador(es) u otros Autores: | Chacón Sánchez C Ochoa Pérez U Coria Lorenzo J Pérez Robles V Garibay Valencia M Fortuño Cordoba V Juárez Olguín H |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Proc West Pharmacol Soc 52():30-2 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2304 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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