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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2286| Título : | Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers |
| Creador: | Riverón Negrete, Leticia |
| Nivel de acceso: | Open access |
| Palabras clave : | Biotina - farmacología Suplementos Dietéticos Hepatocitos - patología Hígado - lesiones Hígado - metabolismo Hígado - patología Hepatopatías - metabolismo Hepatopatías - patología Biotin - pharmacology Dietary Supplements Hepatocytes - metabolism Hepatocytes - pathology Liver - injuries Liver - metabolism Liver - pathology Liver Diseases - metabolism Liver Diseases - pathology Vitamina biotina Coenzima de las carboxilasas Expresión génica Biotina hipolipidémica Hipoglucemia Uso farmacológico de la biotina Secreción de insulina Islotes pancreaticos Toxicidad hepática Biotin Vitamin Coenzyme of the carboxylases Gene Expression Hypolipidemic biotin Hypoglycemia Pharmacological use of biotin Insulin secretion Pancreatic islets Hepatic toxicity |
| Descripción : | Pharmacological concentrations of biotin have pleiotropic effects. Several reports have documented that biotin supplementation decreases hyperglycemia. We have shown that a biotin-supplemented diet increased insulin secretion and the mRNA abundance of proteins regulating insulin transcription and secretion. We also found enlarged pancreatic islets and modified islet morphology. Other studies have shown that pharmacological concentrations of biotin modify tissue structure. Although biotin administration is considered safe, little attention has been given to its effect on tissue structure. In this study, we investigated the effect of biotin supplementation on hepatic morphology and liver toxicity markers. Male BALB/cAnN Hsd mice were fed a control or a biotin-supplemented diet for 8 weeks. Versus the control mice, biotin-supplemented mice had an altered portal triad with dilated sinusoids, increased vascularity, and bile conducts. Furthermore, we observed an increased proportion of nucleomegaly and binucleated hepatocytes. In spite of the liver morphological changes, no differences were observed in the serum liver damage indicators, oxidative stress markers, or antioxidant enzymes. Our data demonstrate for the first time that biotin supplementation affects liver morphology in normal mice, and that these modifications are not paralleled with damage markers. © 2016 Leticia Riverón-Negrete et al. |
| Colaborador(es) u otros Autores: | Sicilia-Argumedo G Álvarez-Delgado C Coballase-Urrutia E Alcántar-Fernández J Fernandez-Mejia C |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1155/2016/7276463 |
| Fuente: | BioMed Research International 2016(2016):1-9 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2286 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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