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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2280| Título : | Diabetes mellitus as a conformational disease: a novel potential therapeutic approach |
| Creador: | Fernández Gómez, Isaac |
| Nivel de acceso: | Open access |
| Palabras clave : | Diabetes Mellitus Tipo 2 - terapia Diabetes Mellitus Tipo 2 - economía Proteínas Amiloidogénicas - uso terapéutico Diabetes Mellitus, Type 2 - therapy Diabetes Mellitus, Type 2 - economics Amyloidogenic Proteins - therapeutic use Diabetes Mellitus Tipo 2 terapia economía Proteínas Amiloidogénicas Diabetes Mellitus, Type 2 therapy economics Amyloidogenic Proteins |
| Descripción : | Type 2 diabetes mellitus is a conformational disease (CD), characterised by deposition (fibrils and cytotoxic oligomers) of the human islet amyloid peptide (hIAPP). CDs have devastating effects on the sufferers and their caregivers, as well as a tremendous economic impact on families and the health system. Novel molecule candidates targeting self-assembled amyloidogenic proteins represent a potential therapeutic approach for CDs. Methods/design: In this work we carried out a systematic study in order to determine the interrelation between the IAPP and IAPP 20–29 fragments in aggregation kinetic with a novel family of naphthalene compounds, used as chemical chaperones. N-(2-aminoethyl)-N′-1-naphthylsuccinamide A; methyl (2-((4-(1-naphthylamino)-4-oxobutanoyl)amino)ethyl) dithiocarbamate B; (2R)-2-(6-methoxy-2-naphthyl)propanoic acid (Naproxen) C; N-(4-(1-naphthylamino)-4-oxobutanoyl)-β-alanine D; 6-((4-(1-naphthylamino)-4-oxobutanoyl)amino) hexanoic acid E; N3,N3′-ethane-1,2-dyilbis(N1-1-naphthylsuccinamide) F; N-(4-aminobutyl)-N′-1-naphthylsuccinamide G; and (1E,6E)-1,8-bis(4-hydroxy-3-methoxyphenyl)octa-1,6-diene-3,5-dione (Curcumine). We describe the structural features, aggregation kinetics, and toxic properties of the, in presence or absence of a novel naphthalene of the chemical chaperones family. |
| Colaborador(es) u otros Autores: | Marquiza Sablón-Carrazana1 2 Alberto Bencomo1 2 Karina Pasten-Hidalgo3 Rosa Angélica Castillo-Rodríguez3 Guadalupe Domínguez5 Reyna Lara6 Luis Felipe Jiménez6 Julio Morán5 Nelly Altamirano-Bustamante7 Sergio Islas-Andrade1 Chryslaine Rodríguez-Tanty2 Eulalia Garrido-Magaña4 & Myriam M Altamirano-Bustamante1 |
| Fecha de publicación : | 2015 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1530/endoabs.37.EP437 |
| Fuente: | Endocrine Abstracts 37():EP437 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2280 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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