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Título : Development of an ultra-performance liquid chromatography-tandem mass spectrometry micromethod for quantification of lamotrigine in human plasma and its use in a bioequivalence trial
Creador: Marcelín Jiménez G
Nivel de acceso: Open access
Palabras clave : Administración Oral - adulto
Anticonvulsivantes - sangre - adulto
Anticonvulsivantes - química - adulto
Anticonvulsivantes - farmacocinética - adulto
Anticonvulsivantes - farmacología - adulto
Antihipertensivos - análisis - adulto
Cromatografía Liquida
femeninos
Guanabenzo - análisis - adulto
Ensayos Analíticos de Alto Rendimiento - adulto
humanos
Reproducibilidad de Resultados
Sensibilidad y Especificidad
Espectrometría de Masa por Ionización de Electrospray
Espectrometría de Masas en Tándem
Triazinas - sangre - adulto
Triazinas - química - adulto
Triazinas - farmacocinética - adulto
Triazinas - farmacología
Administration, Oral - adult
Anticonvulsants - blood - adult
Anticonvulsants - chemistry - adult
Anticonvulsants - pharmacokinetics - adult
Anticonvulsants - pharmacology - adult
Antihypertensive Agents - analysis - adult
Chromatography, Liquid
Female
Guanabenz - analysis - adult
High-Throughput Screening Assays
Humans
Reproducibility of Results
Sensitivity and Specificity
Spectrometry, Mass, Electrospray Ionization
Tandem Mass Spectrometry
Triazines - blood - adult
Triazines - chemistry - adult
Triazines - pharmacokinetics - adult
Triazines - pharmacology - adult
Descripción : The aim of the present work was to develop a chromatographic technique coupled with mass spectrometry for the measurement of lamotrigine in plasma. Lamotrigine and guanabenz (internal standard) were measured by selected reaction monitoring. The method was validated and applied in a bioequivalence trial on 26 female volunteers. Lamotrigine chewable tablets (100 mg) were administered and monitored for up to 96 h. RESULTS: The method was linear between 0.05 and 5.0 µg/ml, with acceptable stability, accuracy and precision. Mean maximum plasma concentration was 1.37 µg/ml and was reached at 1.6 h postdose. Elimination half-life was 32.7 h. CONCLUSION: Lamotrigine tablets were bioequivalent. Ultra-performance liquid chromatography with tandem mass spectrometry represents a powerful tool in terms of sensitivity, specificity and high-throughput analysis
Colaborador(es) u otros Autores: P Angeles Moreno AC
Mendoza-Morales L
Rivera-Espinosa L
Martínez MM
Fecha de publicación : 2009
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : doi: 10.4155/bio.09.8.
Fuente: Bioanalysis 1(1):47-55
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2277
Idioma: eng
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