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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2261| Título : | Detection of circulating and fecal trichinella spiralis antigens during experimental infection using monoclonal antibodies against the new born larvae |
| Creador: | De la Rosa, JL |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Anticuerpos Antihelmínticos Antígenos Helmínticos - análisis Antígenos Helmínticos - sangre Trichinella spiralis - aislamiento y purificación Trichinellosis - sangre Trichinellosis - diagnóstico Animals Antibodies, Helminth Antigens, Helminth - analysis Antigens, Helminth - blood Trichinella spiralis - isolation & purification Trichinellosis - blood Trichinellosis - diagnosis Trichinella antígenos anticuerpos monoclonales Diagnóstico Larva recién nacida Trichinella antigens monoclonal-antibody diagnosis new born larva. |
| Descripción : | Different assays to detect antigens of Trichinella spiralis during current infection have been standardized, although sensitivity values have been the main limitation to use them as routine diagnostic test. We report the production and use of monoclonal antibodies (MAbs) against the new born larvae which recognize both somatic and metabolic antigens from adult and muscular larvae (ML). We used two lgG3 MAbs (4B1, 4B2) and two lgG2a (2D3, 2D4) to detect antigens during experimental infection. All MAbs detect fecal antigens starting the second to third week post infection (wpi), although it was less clear with MAbs 4B1 and 4B2, while circulating antigens were detected from third to fourth wpi. Thus, the recognition of shared antigens among T. spiralis developmental stages can be used for early diagnosis of trichinellosis. |
| Colaborador(es) u otros Autores: | Morán Tlatelpa E Medina Y Gómez Priego A Correa D |
| Fecha de publicación : | 2001 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1051/parasite/200108s2123 |
| Fuente: | Parasite 8(2 suppl.):S123-25 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2261 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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