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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2234| Título : | CYP2D6 genotype and phenotype in Amerindians of Tepehuano origin and Mestizos of Durango, Mexico |
| Creador: | Sosa Macias M |
| Nivel de acceso: | Open access |
| Palabras clave : | Citocromo P-450 CYP2D6 - genética Citocromo P-450 CYP2D6 - metabolismo ADN - análisis Dextrometorfano - sangre Dextrometorfano - farmacocinética Dextrorfano - sangre Frecuencia de los Genes - genética Genotipo - genética Indios Norteamericanos - genética Mediana Edad - Masculino - México fenotipo - genética Polimorfismo Genético - genética Cytochrome P-450 CYP2D6 -genetics Cytochrome P-450 CYP2D6 - metabolism DNA -analysis Dextromethorphan -blood Dextromethorphan - pharmacokinetics Dextrorfano -blood Gene Frequency - genetics Genotype - genetics Indians, North American - genetics Middle Aged - Male - Mexico Phenotype - genetics Polymorphism, Genetic frecuencia de los alelos polimorfismo CYP2D6 diferencias étnicas tepehuanes amerindios, Cytochrome P-450 Allele frequency CYP2D6 polymorphism ethnic difference Tepehuan Amerindians |
| Descripción : | Although the drug-metabolizing enzyme CYP2D6 has been studied extensively in subjects of differing ethnicities, limited CYP2D6 pharmacogenetic data are available for the Amerindian population and Mestizos of Mexico. Dextromethorphan hydroxylation phenotype was studied in Tepehuano Amerindian (n = 58) and Mestizo (n = 88) subjects, and 195 individuals (85 Tepehuano Amerindians and 110 Mestizos) were genotyped by polymerase chain reaction-restriction fragment length polymorphism methods to identify the frequencies of the CYP2D6*3, *4, *6, and *10 alleles. Tepehuano Amerindian subjects lacked the poor metabolizer (PM) phenotype, whereas in Mestizos the PM phenotype frequency was 6.8%. The CYP2D6*3, *6, and *10 alleles were not found in Tepehuano Amerindians. The CYP2D6*4 allele had a low frequency (0.006) in this Amerindian group. In the Mestizo group, the CYP2D6*3, *4, and *10 alleles had frequencies of 0.009, 0.131, and 0.023, respectively. The CYP2D6*6 allele was not found in Mestizos. The genotype-phenotype association was strongly statistically significant (r 2 = .45; P = .005) in Mestizos. The Tepehuano population was found to have a low phenotypic and genotypic CYP2D6 diversity and differed from other Amerindian groups. On the other hand, the frequencies of the CYP2D6 variant alleles in Mestizos were similar to those reported for whites. ©2006 the American College of Clinical Pharmacology. |
| Colaborador(es) u otros Autores: | Elizondo Anzuela G Flores Perez C Flores Perez J Bradley Alvarez F Alanis Bañuelos R Lares Asseff I. |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1177/0091270006287586 |
| Fuente: | Journal of Clinical Pharmacology 46(5):527 - 536 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2234 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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