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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2214| Título : | Congenital and acquired toxoplasmosis: Diversity and role of antibodies in different compartments of the host |
| Creador: | Correa Beltrán, María Dolores |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Anticuerpos Antiprotozoarios - Inmunología Toxoplasmosis - Inmunología Toxoplasmosis Animal - Inmunología Toxoplasmosis Congénita - Inmunología Animals Antibodies, Protozoan - immunology Toxoplasmosis - immunology Toxoplasmosis, Animal - immunology Toxoplasmosis, Congenital - immunology antibodies compartments complement cytokine regulation Toxoplasma gondii toxoplasmosis |
| Descripción : | The apicomplexan parasite Toxoplasma gondii is remarkable in several aspects, since it is a protozoan that infects most nucleated cells in many warm-blooded animals, worldwide. Although the cellular immune response against T. gondii is critical for infection control, antibodies may either enhance or block protective mechanisms, and even mediate immunological damage, directly or indirectly. Since cytokines regulate the class/subclass switch, antibodies may also be the biomarkers of protective or pathological cellular immune events. There is a scientific and clinical interest in the presence of natural and autoreactive antibodies, as well as in the 'chronic' immunoglobulin M (IgM) response and the post-treatment 'rebound'. Another interesting aspect is compartmentalization; certain immunoglobulins may uniquely be found in specific host fluids. Local synthesis has been demonstrated, but antibodies may also traverse several cell layers, like the blood-brain and haemato-ocular barriers, and the placenta. In some instances, Fc receptors (FcRs) facilitate transport and may even have a concentrator effect, which can be related to resistance or pathology. These aspects of the humoral response against T. gondii are reviewed in the present paper. © 2007 The Authors. |
| Colaborador(es) u otros Autores: | Cañedo-Solares B. Ortiz-Alegría H. Caballero-Ortega Rico-Torres |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Revisión |
| Formato: | |
| Identificador del Recurso : | 10.1111/j.1365-3024.2007.00982.x |
| Fuente: | Parasite Immunology 29(12):651 - 660 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2214 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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