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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2211| Título : | Comparison of short-term treatment regimen of ciprofloxacin versus long-term treatment regimens of trimethoprim/sulfamethoxazole or norfloxacin for uncomplicated lower urinary tract infections: A randomized, multicentre, open-label, prospective study |
| Creador: | Arredondo García, José Luis |
| Nivel de acceso: | Open access |
| Palabras clave : | Agentes Antibacterianos - uso terapéutico Ciprofloxacina - administración y dosificación Ciprofloxacina - uso terapéutico Administración de Drogas Norfloxacina - uso terapéutico Sulfametoxazol - uso terapéutico Trimetoprim - uso terapéutico Infecciones del tracto urinario - quimioterapia Anti-Bacterial Agents - therapeutic use Ciprofloxacin - administration & dosage Ciprofloxacin - therapeutic use Drug Administration Schedule Norfloxacin - therapeutic use Sulfamethoxazole - therapeutic use Trimethoprim - therapeutic use Urinary Tract Infections - drug therapy Fluoroquinolonas Ensayos clínicos Cistitis América Latina fluoroquinolones clinical trials cystitis Latin America |
| Descripción : | Objective: To compare the bacteriological and clinical efficacy of three treatments for uncomplicated cystitis in ambulatory pre-menopausal women: ciprofloxacin 250 mg orally twice daily for 3 days, trimethoprim/sulfamethoxazole 160/800 mg orally twice daily for 7 days, and norfloxacin 400 mg orally twice daily for 7 days. Materials and methods: A total of 455 women were randomly assigned to three treatment groups: 151 received ciprofloxacin, 150 received trimethoprim/sulfamethoxazole, and 154 received norfloxacin. Bacteriological cure and clinical resolution were evaluated 5-9 days and 4-6 weeks after completion of treatment. Results: There was no significant difference among the three treatment groups: overall efficacy ranged from 78.5% for the trimethoprim/sulfamethoxazole group, to 84.5% for the ciprofloxacin group. The highest overall incidence of drug-related adverse effects occurred in the trimethoprim/sulfamethoxazole patients. Conclusions: These data indicate that a 3 day treatment with ciprofloxacin is at least as clinically and bacteriologically effective as 7 day treatments with trimethoprim/sulfamethoxazole and norfloxacin for uncomplicated lower urinary tract infections. © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved. |
| Colaborador(es) u otros Autores: | Figueroa Damián R Rosas A Jáuregui A Corral M Costa A Merlos RM Ríos Fabra A Amábile Cuevas CF Hernández Oliva GM Olguín J Cardeñosa Guerra O uUTI Latin American Study Group |
| Fecha de publicación : | 2004 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1093/jac/dkh414 |
| Fuente: | Journal of Antimicrobial Chemotherapy 54(4):840 - 843 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2211 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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