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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2206| Título : | Comparative pharmacokinetics of acetyl salicylic acid and its metabolites in children suffering from autoimmune diseases |
| Creador: | Juárez Olguín, Mateo Hugo |
| Nivel de acceso: | Open access |
| Palabras clave : | Aspirina Aspirina- Farmacocinetica Artritis Juvenil Artritis Juvenil - Metabolismo Fiebre Reumática Aspirin Arthritis, Juvenile Arthritis, Juvenile - Metabolism Aspirin - Pharmacokinetics Rheumatic Fever aspirina Artritis reumatoide juvenil metabolismo farmacocinética fiebre reumática salicilatos Aspirin Juvenile rheumatoid arthritis Metabolism Pharmacokinetics Rheumatic fever salicylates |
| Descripción : | The aim of the present study was to compare the effect produced by juvenile rheumatoid arthritis (JRA) or rheumatic fever (RF) on the pharmacokinetics of acetyl salicylic acid (ASA) and its metabolites in children with autoimmune diseases (AD). Methods - A prospective, open labelled study was performed in 17 children with JRA and 17 with RF who received a single dose of 25 mg ASA/kg orally. The pharmacokinetics of ASA and its metabolites were determined. The blood and urine levels of each salicylate collected during 24h were measured by HPLC. A group of 15 healthy teenage volunteers was included as a control group. Results - The maximum plasma concentration, half-life time, area under the curve and the amount of salicylates excreted were statistically different between the JRA and the RF groups, as well as between the RF group and the controls, however, there were no significant differences between the JRA group and the controls. Conclusions - Dosage schemes must be adjusted for JRA patients, since the half life in these patients is longer than in RF patients. However, due to ample variability of pharmacokinetic parameters it is recommended that dose schemes are individualized on the type of autoimmune disease considered. Copyright © 2004 John Wiley & Sons, Ltd. |
| Colaborador(es) u otros Autores: | Flores Perez J Lares Asseff I Loredo Abdala A Carbajal Gutierrez L |
| Fecha de publicación : | 2004 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1002/bdd.379 |
| Fuente: | Biopharmaceutics and Drug Disposition 25(1):1 - 7 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2206 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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