Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2205
Título : Comparative effects of catechin, epicatechin and N-Ω- nitroarginine on quinolinic acid-induced oxidative stress in rat striatum slices
Creador: Santamaría Del Ángel Daniel
Nivel de acceso: Open access
Palabras clave : Animales
Catequina - farmacología
Cuerpo Estriado - patología
Disulfuro de Glutatión - metabolismo
Peroxidación de Lípido - efectos de drogas
Lípidos - química
masculino
Nitroarginina - farmacología
Estrés Oxidativo - efectos de drogas
Ácido Quinolínico - toxicidad
Ratas Wistar
Animals
Catechin - pharmacology
Corpus Striatum - pathology
Glutathione Disulfide - metabolism
Lipid Peroxidation - drug effects
Lipids - chemistry
Male
Nitroarginine - pharmacology
Oxidative Stress - drug effects
Quinolinic Acid - toxicity
Rats, Wistar
Cerebro; Excitotoxicidad; Flavonoides; Gluthation; Peroxidación de los lípidos; Óxidonítrico; Daño oxidativo
Brain; Excitotoxicity; Flavonoids; Gluthation; Lipid Peroxidation; Nitric oxide; Oxidative damage
Descripción : The aim of this work was to compare the effects of catechin (CAT), epicatechin (EPI) and N-ω-l-nitroarginine (L-NARG) on different endpoints of oxidative stress induced by quinolinic acid (QUIN) in a simple tissue preparation, rat striatal slices - with particular emphasis in the glutathione system - in order to provide revealing information on the antioxidant efficacy of these agents in an excitotoxic model. Methods: Rat striatal slices were incubated for 1 h in the presence of 100 μM QUIN and/or 85 μM CAT or EPI, or 100 μM L-NARG. Lipid peroxidation (LP) and the levels of reduced and oxidized glutathione (GSH and GSSG) were determined. Results: The three agents tested completely blocked the QUIN-induced lipid peroxidation and recovered the QUIN-induced altered GSH/GSSG balance. No statistical differences were detected among the protective effects exerted by these antioxidants, suggesting similar efficacy and common antioxidant mechanisms. The antioxidant properties exhibited by these molecules on the excitotoxic model tested herein support an active role of glutathione and prompt their use as therapeutic tools in models of neurodegenerative disorders. © 2016 Elsevier Masson SAS.
Colaborador(es) u otros Autores: Labra Ruíz Norma Angélica
García-Cruz Mercedes Edna
Calderón Guzmán David
Valenzuela Peraza Armando
Juárez-Olguín Hugo
Fecha de publicación : 2016
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.biopha.2016.01.016
Fuente: Biomedicine and Pharmacotherapy 78():210 - 215
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2205
Idioma: eng
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