Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2204
Título : Comparative effect of cyanamide and sodium nitroprusside on indolamine and lipid peroxidation levels in rat brain
Creador: Calderón Guzmán, David
Nivel de acceso: Open access
Palabras clave : Química Encefálica - efectos de drogas
Cianamida - farmacología
Indoles - metabolismo
Peroxidación de Lípido - efectos de drogas
Nitroprusiato - farmacología
Ratas
Indoles
Nitratos
Nitroprusiato
Serotonina
Cianamida
Brain Chemistry - Drug effects
Cyanamide - Pharmacology
Lipid Peroxidation - Drug effects
Nitroprusside - Pharmacology
Rats
Indoles
Nitrates
Nitroprusside
Serotonin
Cyanamide
cyanamide; indoleamine; nitrate; nitric oxide; nitrite; nitroprusside sodium; serotonin; thiobarbituric acid reactive substance; tryptophan; animal cell; animal experiment; animal model; animal tissue; brain homogenate; conference paper; controlled study; decapitation; drug activity; drug effect; lipid peroxidation; liquid chromatography; male; nonhuman; oxidative stress; rat; Animals; Biogenic Amines; Brain Chemistry; Chromatography, High Pressure Liquid; Cyanamide; Indicators and Reagents; Indoles; Lipid Peroxidation; Male; Nitrates; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Serotonin; Spectrophotometry, Ultraviolet; Thiobarbituric Acid Reactive Substances
Descripción : The aim of this study was to compare the effect of cyanamide (CNM) and sodium nitroprusside (SNP) on nitrite (NO 2 -) and nitrate (NO 3 -), stable metabolites of nitric oxide (NO), serotonin (5-HT), tryptophan (Trp), and lipid peroxidation (TBARS) levels in rat brain. Twenty-four male Wistar rats (350 g) were used, divided in 3 groups of 8 animals each. Control group I received 0.9 % NaCl, CNM (40 mg/kg) was administered to group II, and SNP (20 pg/kg) to group III; all animals received a single intraperitoneal dose. The animals were sacrificed by decapitation and the brain was homogenized to measure the NO 2 -, NO 3 -, 5-HT, and Trp levels by liquid chromatography, and TBARS levels by spectrophotometry. NO 2 - levels significantly increased (p < 0.01) in the CNM group, while 5-HT and TBARS significantly increased (p = 0.001) both in SNP and CNM groups in relation to the control group. Trp levels presented a slight increase in the CNM group with respect to the control group. The results suggest that free radicals (Nitroxyl and NO) generated by CNM and SNP, respectively, are responsible for oxidative stress induced in brain.
Colaborador(es) u otros Autores: Espitia Vazquez Ivonne
Barragan Mejía Gerardo
Hernández García Ernestina
Huerta Gertrudis Bernardino
Coballase Urrutia Elvia
Santamaria Del Angel Daniel
Juárez Olguin Hugo
Fecha de publicación : 2004
Tipo de publicación: Otros
Formato: pdf
Fuente: Proceedings of the Western Pharmacology Society 47():105 - 108
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2204
Idioma: eng
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