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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2157| Título : | Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats |
| Creador: | Guarner Lans Verónica |
| Nivel de acceso: | Open access |
| Palabras clave : | Receptores de Angiotensina - ultraestructura, Receptores de Angiotensina - sangre Receptores de Angiotensina - metabolismo Receptores de Angiotensina - uso terapéutico Aorta Torácica - anatomía & histología Aorta Torácica - patología Aorta Torácica - embriología Aorta Torácica -química Aorta Torácica - ultraestructura Aorta Torácica - metabolismo Presión Arterial - fisiología Microscopía Electrónica Fluorescencia Trastornos del Metabolismo de los Lípidos - terapia Trastornos del Metabolismo de los Lípidos - inducido químicamente Trastornos del Metabolismo de los Lípidos - patología Trastornos del Metabolismo de los Lípidos - sangre Endotelio Vascular - citología Endotelio Vascular - ultraestructura Endotelio Vascular - embriología Endotelio Vascular - patología Receptors, Angiotensin - ultrastructure Receptors, Angiotensin - blood Receptors, Angiotensin - metabolism Receptors, Angiotensin - therapeutic use Aorta, Thoracic - anatomy & histology Aorta, Thoracic - pathology Aorta, Thoracic - embryology Aorta, Thoracic - chemistry Aorta, Thoracic - ultrastructure Aorta, Thoracic - metabolism Arterial Pressure - physiology Microscopy, Electron Fluorescence Lipid Metabolism Disorders - therapy Lipid Metabolism Disorders - chemically induced Lipid Metabolism Disorders - pathology Lipid Metabolism Disorders - blood Endothelium, Vascular - cytology Endothelium, Vascular - ultrastructure Endothelium, Vascular - embriology Endothelium, Vascular - pathology Angiotensina, Arco de la Aorta, metabolismo, Endotelio Capilar Angiotensins, Aorta, Thoracic , metabolism, Endothelium, Vascular |
| Descripción : | The role of the renin-angiotensin system (RAS) in blood pressure regulation in MS during aging is unknown. It participates in metabolic syndrome (MS) and aging regulating vascular tone and remodeling. RAS might participate in a compensatory mechanism decreasing blood pressure and allowing MS rats to reach 18 months of age and it might form part of therapeutical procedures to ameliorate MS. We studied histological changes and distribution of RAS receptors in aortas of MS aged rats. Electron microscopy images showed premature aging in MS since the increased fibrosis, enlarged endothelium, and invasion of this layer by muscle cells that was present in control 18-month-old aortas were also found in 6-month-old aortas from MS rats. AT1, AT2, and Mas receptors mediate the effects of Ang II and Ang 1-7, respectively. Fluorescence from AT2 decreased with age in control and MS aortas, while fluorescence of AT1 increased in aortas from MS rats at 6 months and diminished during aging. Mas expression increased in MS rats and remained unchanged in control rats. In conclusion, there is premature aging in the aortas from MS rats and the elevated expression of Mas receptor might contribute to decrease blood pressure during aging in MS. © 2016 Verónica Guarner-Lans et al. |
| Colaborador(es) u otros Autores: | Soria-Castro Elizabeth Rocío Torrico-Lavayen Rocío Patrón-Soberano Araceli Carvajal-Aguilera Karla G. Castrejón-Tellez Vicente Rubio-Ruiz María Esther |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1155/2016/5830192 |
| Fuente: | International Journal of Hypertension 2016():1 - 11 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2157 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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