Cellular immune response and Th1/Th2 cytokines in human neurocysticercosis: lack of immune suppression.

Medina Escutia, Edith

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Título :	Cellular immune response and Th1/Th2 cytokines in human neurocysticercosis: lack of immune suppression.
Creador:	Medina Escutia, Edith
Nivel de acceso:	Open access
Palabras clave :	Citoquinas - biosíntesis Tolerancia inmunológica Neurocisticercosis - Inmunología Cytokines - biosynthesis Immune Tolerance Neurocysticercosis - immunology
Descripción :	Some reports have suggested that human neurocysticercosis (NCC) induces immunosuppression. To test this hypothesis, we performed a study on active cases of NCC who had not received cestocidal or immunosuppressive treatments. We examined blood counts and specific T cell markers (CD3, CD4, and CD8) by flow cytometry and found no differences between patients with NCC and healthy individuals. Both groups responded to concanavalin A (Con A), and patients with NCC responded more to a parasite crude antigen than uninfected individuals. Peripheral blood mononuclear cells were examined for interleukin (IL)-2, interferon-gamma, IL-10, and IL-4 mRNA. Regardless of infection status, more than 60% of individuals synthesized IL-2 mRNA and, less frequently, the other cytokines. These data suggest that immunosuppression does not occur in NCC patients.
Colaborador(es) u otros Autores:	Morales López Zoila Proaño Jefferson V Vázquez José Bermúdez Victor Ortiz Navarrete Vianney Madridmarina Vicente Laclette Juan P Correa Dolores
Fecha de publicación :	2001
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1645/0022-3395(2001)087[0587:CIRATT]2.0.CO;2
Fuente:	J Parasitol 87(3):587-590
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2149
Idioma:	eng
Aparece en las colecciones:	Artículos

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