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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2145| Título : | Castration modifies aortic vasoreactivity and serum fatty acids in a sucrose-fed rat model of metabolic syndrome |
| Creador: | Perez I |
| Nivel de acceso: | Open access |
| Palabras clave : | Aorta - metabolismo - ratas Aorta - fisiopatología - ratas Presión Sanguínea - ratas Peso Corporal - ratas Sacarosa en la Dieta - ratas Ácidos Grasos - sangre - ratas Hemodinámica - ratas Síndrome X Metabólico - metabolismo - ratas Síndrome X Metabólico - fisiopatología - ratas Síndrome X Metabólico - prevención & control - ratas Orquiectomía - - ratas Ratas Wistar Testosterona - sangre - ratas Factores de Tiempo Triglicéridos - sangre - ratas Vasoconstricción - ratas Vasodilatación - ratas Aorta - metabolism - rats Aorta - physiopathology - rats Blood Pressure Body Weight - rats Dietary Sucrose - rats Fatty Acids - blood - rats Hemodinámica - rats Metabolic Syndrome X - metabolism - rats Metabolic Syndrome X - physiopathology - rats Metabolic Syndrome X - prevention & control - rats Orchiectomy - rats Rats, Wistar Testosterone - blood - rats Time Factors Triglycerides - blood - rats Vasoconstriction - rats Vasodilation - rats Síndrome metabólico de la rata, Castración, Vascular, reactividad, Ácidos grasos libres Rat metabolic syndrome · Castration · Vascular reactivity · Free fatty acids |
| Descripción : | Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasoreactivity, serum lipid content, and systolic blood pressure (SBP) in rats with sucrose-induced metabolic syndrome. The main characteristics of the rat model are: hypertriglyceridemia, moderately high blood pressure, intra-abdominal accumulation of adipose tissue, hyperinsulinemia, nephropathy, increased oxidative stress, and altered vasoreactivity. Male weanling rats received 30% sucrose solution for 16 weeks (metabolic syndrome; MS), controls (C) had plain water; both had commercial rodent chow. They were subdivided into five groups with two subgroups each: Group 1, intact C and MS rats, Groups 2-5, C and MS rats castrated for periods of 16, 12, 8, and 4 weeks. At the end of the study period, systolic blood pressure was measured, and blood and aortas were obtained for fatty acid determination and vasoreactivity assays, respectively. After 16 weeks' sucrose treatment MS aortas showed hypercontractility and decreased vasodilation. Palmitic and palmitoleic acids were increased in MS versus C. Arachidonic acid levels in MS were lower than in intact or castrated C. Long-term castration of 16 weeks normalized the levels of palmitic and oleic acids. With the shorter periods of castration, contractility increased and relaxation decreased in C and MS, but it was more significant in C. Regarding fatty acid composition, long-term castration increased polyunsaturated (arachidonic and eicosapentaenoic) fatty acids. The shorter periods did not modify the fatty acid profile in either C or MS. Metabolic syndrome altered SBP, aortic reactivity, and levels of fatty acids; castration of long duration normalized them in some cases |
| Colaborador(es) u otros Autores: | El Hafidi M Carvajal K Baños G |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1007/s00380-008-1098-x |
| Fuente: | Heart Vessels 24(2):147-55 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2145 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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