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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2138| Título : | Canines as sentinel species for assessing chronic exposures to air pollutants part 2. Cardiac pathology |
| Creador: | Calderón Garcidueñas, Lilian |
| Nivel de acceso: | Open access |
| Palabras clave : | Contaminantes del Aire - toxicidad Perros - fisiología Corazón - efectos de drogas México Modelos animales Miocardio - patología Miocardio - ultraestructura Ozono - toxicidad Air Pollutants - toxicity Dogs - physiology Heart - drug effects Mexico Models, Animal Myocardium - pathology Myocardium - ultrastructure Ozone - toxicity la contaminación del aire ambiente perros miocardio mastocitos materia particular ozono miocitos apoptóticas y las células endoteliales lesión endotelial Ciudad de México ambient air pollution dogs myocardium mast cells particulate matter ozone apoptotic myocytes and endothelial cells endothelial injury Mexico City |
| Descripción : | The principal objective of this study is to evaluate by light and electron microscopy (LM, EM) the heart tissues in stray southwest and northeast metropolitan Mexico City (SWMMC, NEMMC) dogs and compare their findings to those from 3 less polluted cities (Cuernavaca, Tlaxcala, and Tuxpam). Clinically healthy mongrel dogs, including 109 from highly polluted SWMMC and NEMMC, and 43 dogs from less polluted cities were studied. Dogs residing in cities with lower levels of pollutants showed little or no cardiac abnormalities. Mexico City and Cuernavaca dogs exhibited LM myocardial alterations including apoptotic myocytes, endothelial and immune effector cells, degranulated mast cells associated with scattered foci of mononuclear cells in left and right ventricles and interventricular septum, and clusters of adipocytes interspersed with mononuclear cells. Vascular changes included scattered polymorphonuclear leukocytes (PMN) margination and microthrombi in capillaries, and small venous and arteriolar blood vessels. Small veins exhibited smooth muscle cell hyperplasia, and arteriolar blood vessels showed deposition of particulate matter (PM) in the media and adventitia. Unmyelinated nerve fibers showed endoneural and epineural degranulated mast cells. EM examination of myocardial mast cells showed distended and abundant rough endoplasmic reticulum with few secretory granules. Myocardial capillaries exhibited fibrin deposition and their endothelial cells displayed increased luminal and abluminal pinocytic activity and the formation of anemone-like protrusions of the endothelium into the lumen. A close association between myocardial findings, lung epithelial and endothelial pathology, and chronic inflammatory lung changes was noted. The myocardial changes described in dogs exposed to ambient air pollutants may form the basis for developing hypothesis-driven mechanistic studies that might explain the epidemiological data of increased cardiovascular morbidity and mortality in people exposed to air pollutants. |
| Colaborador(es) u otros Autores: | Gambling TM Acuña H García R Osnaya N Monroy S Villarreal Calderón A Carson J Koren HS Devlin RB |
| Fecha de publicación : | 2001 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1093/toxsci/61.2.356 |
| Fuente: | Toxicological Sciences 61(2):356 - 367 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2138 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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