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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2132| Título : | A multi-country study of intussusception in children under 2 years of age in Latin America: Analysis of prospective surveillance data |
| Creador: | Sáez Llorens, Xavier |
| Nivel de acceso: | Open access |
| Palabras clave : | Preescolar Estudios Transversales Femenino Humanos Incidencia Lactante Intususcepción - epidemiología Intususcepción - cirugía América Latina Masculino Estudios Prospectivos Vacunas contra Rotavirus Child, Preschool Cross-Sectional Studies Female Humans Incidence Infant Intussusception - epidemiology Intussusception - surgery Latin America Male Prospective Studies Rotavirus Vaccines Children Intussusception Latin America Multi country Rotavirus Vaccination |
| Descripción : | Background: Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction.Methods: Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines.Results: From 517 potential cases identified, 476 (92%) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89% of cases aged <1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children <2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged <1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65%). Most cases (88%) made a complete recovery, but 13 (3%) died. No clear seasonal pattern of IS cases emerged.Conclusions: This study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies. Trial registration: Clinical study identifier 999910/204 (SERO-EPI-IS-204). © 2013 Sáez-Llorens et al.; licensee BioMed Central Ltd. |
| Colaborador(es) u otros Autores: | Velázquez F.R. Lopez P. Espinoza F. Linhares A.C. Abate H. Nuñez E. Venegas G. Vergara R. Jímenez A.L. Rivera M. Aranza C. Richardson V. Macias-Parra M. Palacios G.R. Rivera L. Ortega-Barria E. Cervantes Y. Rattimann R. Rubio P. Acosta C.J. Newbern C. Verstraeten T. Breuer T. |
| Fecha de publicación : | 2013 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1186/1471-230X-13-95 |
| Fuente: | BMC Gastroenterology 13(1):1-8 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2132 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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