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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2129| Título : | Brain thiobarbituric acid-reactive substances in rats after short periods of ozone exposure |
| Creador: | Escalante Membrillo C |
| Nivel de acceso: | Open access |
| Palabras clave : | Contaminantes del Aire - toxicidad Cerebro - efectos de drogas Peroxidación de Lípido - Efectos de drogas Ozono - Toxicidad Sustancias Reactivas al Ácido Tiobarbitúrico - Metabolismo Ratas Air Pollutants - Toxicity Brain - Drug effects Lipid Peroxidation - Drug effects Ozone - Toxicity Thiobarbituric Acid Reactive Substances - Metabolism Rats Ozono Peroxidación de los lípidos TBARS Cerebro Radicales libres Ozone Lipid peroxidation TBARS Brain Free radicals |
| Descripción : | It has been proposed that molecules derived from reactions that occur between the ozone and the lung tissue mediate nonpulmonary effects caused by ozone exposure. Free radicals are among those proposed molecules that flow throughout the bloodstream to other organs producing lipid peroxidation. In order to elucidate on aspect of ozone toxicity mechanisms, we measured the thiobarbituric acid-reactive products (TBARS), as an index of lipid peroxidation, in a variety of brain regions in rats exposed to 1 ppm of ozone for 1, 3, 6, and 9 h. Another group exposed to 9 h of O3 plus 3 h of clean-air exposure was also included. The results showed an important increase in TBARS content in all the studied structures. Such effect seems to be transient. These findings indicates that acute ozone exposure can produce cerebral peroxidation as it has been found in rats exposed chronically, suggesting an involvement of free radicals in brain effects of ozone exposure. |
| Colaborador(es) u otros Autores: | Gonzalez Maciel A Reynoso Robles R Gonzalez Pina R. |
| Fecha de publicación : | 2005 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.envres.2005.02.006 |
| Fuente: | Environmental Research 99(1):68-71 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2129 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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