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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2128| Título : | Brain plasticity, signal transduction and epigenesis: A missing link revealed |
| Creador: | Báez Saldaña, Armida |
| Nivel de acceso: | Open access |
| Palabras clave : | Plasticidad Neuronal - genética Epigénesis Genética - genética Epigénesis Genética - fisiología Represión Epigenética - genética Represión Epigenética - fisiología Cromatina - genética Cromatina - fisiología Reología - métodos Expresión Génica - genética Neuronal Plasticity - genetics Epigenesis, Genetic - genetics Epigenesis, Genetic - physiology Epigenetic Repression - genética Epigenetic Repression - physiology Chromatin - genetics Chromatin - physiology Rheology - methods Gene expression - genetics vías de transducción de señal, mecanismos epigenéticos, remodelación de la cromatina, expresión génica, plasticidad neuronal signal transduction pathways, epigenetic mechanisms, chromatin remodeling, gene expression, neuronal plasticity |
| Descripción : | It has been long thought that the brain reorganizes itself in response to environmental needs. Sensory experiences coded in action potentials are the mean by which information on the surroundings is introduced into neuronal networks. The information approaching the brain in the form of electrochemical codes must then be translated in biochemical, epigenetic and genetic ones. Only until recently we have begun understanding the underpinning of such informational transformations and how this process is expressed as neuronal plastic responses. Central for our comprehension of this matter is the finding that signals transduction cascades can modify gene expression by remodeling the chromatin through epigenetic mechanisms. Hence, chromatin remodeling seems to be the process by which experiences are "imprinted" in the genome leading to differential gene expression and brain plasticity. In this review, we briefly comment on this possibility. © by São Paulo State University. |
| Colaborador(es) u otros Autores: | Fetter-Pruneda Ingrid Fuentes-Farías Alma L. Granados-Rojas Leticia Gutiérrez-Ospina Gabriel Martínez-Méndez Raquel Meléndez-Herrera Esperanza Mendoza-Torreblanca Julieta Sandoval-Velasco Marcela |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.5016/1806-8774.2009v11pT114 |
| Fuente: | Annual Review of Biomedical Sciences 11():114 - 122 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2128 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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