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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2126| Título : | Blood SC5b-9 complement levels increase at parturition during term and preterm labor |
| Creador: | Segura Cervantes, Enrique |
| Nivel de acceso: | Open access |
| Palabras clave : | Adulto Complejo de Ataque a Membrana del Sistema Complemento - metabolismo Estudios Transversales Membranas Extraembrionarias - metabolismo Femenino Humanos Parto - sangre Embarazo Nacimiento Prematuro - sangre Adult Complement Membrane Attack Complex - metabolism Cross-Sectional Studies Extraembryonic Membranes - metabolism Female Humans Parturition - blood Pregnancy Premature Birth - blood Complemento Membranas fetales Trabajo Parto Embarazo Complement Fetal membranes Labor Parturition Pregnancy |
| Descripción : | We explored the hypothesis that complement, an innate and adaptive immune effector, is active in the plasma of parturient women and is deposited on fetal membranes collected after delivery. A cross-sectional study was designed to evaluate complement activity at parturition. Pregnant women (n = 97) between 15 and 41 years of age were enrolled in a hospital protocol during the perinatal period to assess both SC5b-9 complement activity in blood and complement deposition on fetal membranes during parturition. Soluble SC5b-9 complement activity in plasma fractions was measured using a standard enzyme-linked immunosorbent assay (ELISA) that included specific anti-complement antibodies. Complement deposition on membranes was analyzed using immuno-dot blots and immunohistochemistry. Soluble SC5b-9 complement complex levels were increased in the plasma of women during term labor (TL; median 3361; range 1726-5670 ng/mL), preterm labor (PL; median 2958; range 1552-7092 ng/mL), and preterm premature rupture of membranes (PPROM; median 2272; range 167-6540 ng/mL) compared with pregnant women who were not in labor (P; median 1384; range 174-4570 ng/mL; P < 0.001, Kruskal-Wallis test). Active complement, as assessed by the C9 neo-antigen in C5b-9 complexes, was deposited on fetal membranes, with no difference between term and preterm delivery. The deposition of active complement on fetal membranes was confirmed by immunohistochemistry. Women who underwent non-labor-indicated Cesarean sections did not exhibit complement deposition. Soluble SC5b-9 complement complex levels increased in the plasma of women during parturition, and complement C5b-9 complexes were deposited on fetal membranes. |
| Colaborador(es) u otros Autores: | Mancilla-Ramirez Javier Zurita Luis Paredes Yuriria Arredondo Garcia José Luis Galindo-Sevilla Norma |
| Fecha de publicación : | 2015 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.jri.2015.02.008 |
| Fuente: | Journal of Reproductive Immunology 109():24-30 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2126 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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