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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2118| Título : | Biotin deficiency and biotin excess: effects on the female reproductive system |
| Creador: | Báez Saldaña, Armida |
| Nivel de acceso: | Open access |
| Palabras clave : | Biotina - administración & dosificación - ratones Biotina - sangre - ratones Biotina - deficiencia - ratones Biotina - farmacología - ratones Peso Corporal - efectos de drogas - ratones Dieta - ratones Estradiol - sangre - ratones Ciclo Estral - efectos de drogas - ratones femenino - ratones Hígado - anatomía & histología - ratones Hígado - efectos de drogas - ratones Hígado - enzimología - ratones Ratones Consanguíneos BALB C Tamaño de los Órganos - efectos de drogas - ratones Ovario - anatomía & histología - ratones Ovario - efectos de drogas - ratones Progesterona - sangre - ratones ARN Mensajero - metabolismo - ratones Receptores de Estradiol - genética - ratones Receptores de Progesterona - genética - ratones Reproducción - efectos de drogas - ratones Reproducción - fisiología - ratones Útero - efectos de drogas - ratones Útero - metabolismo - ratones Biotin - administration & dosage - Mice Biotin - blood - Mice Biotin - deficiency - Mice Biotin - pharmacology- Mice Body Weight - drug effects - Mice Diet - Mice Estradiol - blood - Mice Estrous Cycle - drug effects - Mice Female - Mice Liver - anatomy & histology - Mice Liver -drug effects - Mice Liver - enzymology - Mice Mice, Inbred BALB C Organ Size - drug effects - Mice Ovary - anatomy & histology - Mice Ovary - drug effects - Mice Progesterone - blood - Mice RNA, Messenger - genetics - Mice RNA, Messenger - metabolism - Mice Receptors, Estradiol - genetics - Mice Receptors, Progesterone - genetics - Mice Reproduction - drug effects - Mice Reproduction - physiology - Mice Uterus - drug effects - Mice Uterus - metabolism - Mice Biotina, Estradiol, Progesterona, Receptores de esteroides sexuales, CYP, Ovario Biotin Estradiol Progesterone Sex steroid receptors CYP Ovary |
| Descripción : | Biotin deficiency and biotin excess have both been found to affect reproduction and cause teratogenic effects. In the reproductive tract, however, the effects of biotin have not been well established yet. We investigated the effects of varying biotin content diets on the oestrus cycle, ovarian morphology, estradiol and progesterone serum levels, and the uterine mRNA abundance of their nuclear receptors, as well as on the activity of the estradiol-degrading group of enzymes cytochrome P450 (CYP) in the liver. Three-week-old female BALB/cAnN Hsd mice were fed a biotin-deficient, a biotin-control, or a biotin-supplemented diet (0, 7.2 or 400 micromol of free biotin/kg diet, respectively) over a period of nine weeks. Striking effects were observed in the biotin-deficient group: mice showed arrested estrous cycle on the day of diestrus and changes in ovary morphology. Estradiol serum concentration increased 49.2% in biotin-deficient mice compared to the control group, while the enzymatic activities of CYP1A2 and CYP2B2 increased (P<0.05). The mRNA abundance of nuclear estrogen and progesterone receptors decreased in the biotin-deficient mice. In the biotin-supplemented group we found that, in spite of a significant (P<0.05) decrease in the number of primary and Graafian follicles and in CYP1A2 activities, mice exhibited 105.4% higher serum estradiol concentration than the control group. No changes in the expression of the nuclear receptors were observed. No significant differences were observed in serum progesterone among the groups. Our results indicate that both the deficiency and the excess of biotin have significant effects on the female mouse reproductive system |
| Colaborador(es) u otros Autores: | Camacho-Arroyo I Espinosa-Aguirre JJ Neri-Gómez T Rojas-Ochoa A Guerra-Araiza C Larrieta E Vital P Díaz G Chavira R Fernández-Mejía C. |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.steroids.2009.06.004 |
| Fuente: | Steroids 74(10-11):863-69 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2118 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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