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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2115| Título : | Bioavailability of an extemporaneous suspension of propafenone made from tablets |
| Creador: | Juárez Olguín, Mateo Hugo |
| Nivel de acceso: | Open access |
| Palabras clave : | Administración Oral - Conejos Antiarrítmicos - administración & dosificación - Conejos Antiarrítmicos - sangre - Conejos Antiarrítmicos - farmacocinética - Conejos Disponibilidad Biológica - Conejos Estabilidad de Medicamentos - Conejos Inyecciones Intravenosas - Conejos Propafenona - administración & dosificación - Conejos Propafenona - sangre - Conejos Propafenona - farmacocinética - Conejos Suspensiones - Conejos Comprimidos - Conejos Administration, Oral - Rabbits Anti-Arrhythmia Agents - administration & dosage - Rabbits Anti-Arrhythmia Agents -blood - Rabbits, Anti-Arrhythmia Agents - pharmacokinetics - Rabbits Biological Availability - Rabbits Drug Stability - Rabbits Injections, Intravenous - Rabbits Propafenone -administration & dosage - Rabbits Propafenone - blood - Rabbits Propafenone - pharmacokinetics - Rabbits Suspensions - Rabbits Tablets - Rabbits Antiarrítmicos Propafenona Suspensiones Comprimidos Conejos Anti-Arrhythmia Agents Propafenone Suspensions Tablets Rabbits |
| Descripción : | Propafenone is an effective antiarrhythmic agent used in children, while in Mexico no specific formulation for children is available, which causes errors in adequate dosage. The aim of this study was to determine the bioavailability of a suspension prepared extemporaneously using commercial tablets of propafenone. The bioavailability was determined in two groups of rabbits (n = 8): the first group received a single intravenous dose of 2 mg/kg of propafenone; the second was orally administered an extemporaneous suspension of propafenone prepared from commercial tablets. Blood samples were drawn at several times during the next 24 h and analysed by HPLC to determine drug levels. The extemporaneous suspension was tested previously with satisfactory results regarding physicochemical and microbiologic stability. The area under the curve (AUC) for the i.v. route was 5600.6 ng/ml.h and for oral administration the AUC was 3327.6 ng/ml.h. The bioavailability was calculated at 59.41%. These results are consistent with previous reports for solid dosage forms. The propafenone suspension prepared extemporaneously using commercial tablets is bioavailable using an animal model; nevertheless, it is necessary to carry out human studies either in volunteers or in patients to confirm these results. Copyright © 2006 John Wiley & Sons, Ltd |
| Colaborador(es) u otros Autores: | Flores Pérez Carmen Flores Pérez Janett Ramíres Mendiola Blanca Carrasco Portugal Miriam Bobadilla Chávez Jesús |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1002/bdd.505 |
| Fuente: | Biopharmaceutics and Drug Disposition 27(5):241-245 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2115 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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