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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2099| Título : | Influenza aviar: evolución genética bajo presión de vacunación. Avian influenza: Genetic evolution under vaccination pressure |
| Creador: | Escorcia M |
| Nivel de acceso: | Open access |
| Palabras clave : | Enfermedades Endémicas - veterinaria Vacunas contra la Influenza - inmunología Gripe Aviar - inmunología Gripe aviar - virología Selección Genética Endemic Diseases - veterinary Influenza Vaccines - immunology Influenza in Birds - immunology Influenza in Birds - virology Selection, Genetic Inluenza aviar vacunas virus Avian Influenza Vaccines virus |
| Descripción : | Antigenic drift of avian influenza viruses (AIVs) has been observed in chickens after extended vaccination program, similar to those observed with human influenza viruses. To evaluate the evolutionary properties of endemic AIV under high vaccination pressure (around 2 billion doses used in the last 12 years), we performed a pilot phylogenic analysis of the hemagglutinin (HA) gene of AIVs isolated from 1994 to 2006. This study demonstrates that Mexican low pathogenicity (LP) H5N2-AIVs are constantly undergoing genetic drifts. Recent AIV isolates (2002-2006) show significant molecular drifts when compared with the H5N2 vaccine-strain or other field isolates (1994-2000). This study also demonstrates that molecular drifts in the HA gene lineages follow a yearly trend, suggesting gradually cumulative sequence mutations. These findings might explain the increasing incidence of LP H5N2 AIV isolated from commercial avian farms. These findings support recent concerns about the challenge of AIV antigenic drift and influenza epidemics. © 2008 Escorcia et al; licensee BioMed Central Ltd. |
| Colaborador(es) u otros Autores: | Vázquez L Méndez ST Rodríguez-Ropón A Lucio E Nava GM |
| Fecha de publicación : | 2008 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1186/1743-422X-5-15 |
| Fuente: | Virology Journal 5(15):1- 15 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2099 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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