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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1970| Título : | Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children |
| Creador: | Meza Velázquez, MR |
| Nivel de acceso: | Open access |
| Palabras clave : | Amina Oxidasa (conteniendo Cobre) - genética Niño Preescolar Análisis Mutacional de ADN Progresión de la Enfermedad Femenino Frecuencia de los Genes Estudios de Asociación Genética Predisposición Genética a la Enfermedad Genotipo Histamina - sangre Histamina N-Metiltransferasa - genética Humanos Inmunoglobulina E - sangre Masculino México Polimorfismo de Nucleótido Simple Rinitis Alérgica - genética Amine Oxidase (Copper-Containing) - genetics Child Child, Preschool DNA Mutational Analysis Disease Progression Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Histamine - blood Histamine N-Methyltransferase - genetics Humans Immunoglobulin E - blood Male Mexico Polymorphism, Single Nucleotide Rhinitis, Allergic - genetics Rinitis Alérgica Histaminasa Histamina Histamina Metiltransferasa Polimorfismo Allergic rhinitis; Diamine oxidase; Histamine; Histamine N-methyl transferase; Polymorphisms |
| Descripción : | Background: It has been suggested that polymorphisms of histamine metabolising enzymes can be a risk factor for developing histamine-involving diseases. The aim of the present study is to research the possible association between two functional single nucleotide polymorphisms (SNPs): C314T in the Histamine-N-Methyl Transferase gene and C2029G in the Diamine Oxidase gene, with the severity of allergic rhinitis and the number of allergic diseases, in a group of allergic Mexican children. Methods: We studied 154 unrelated allergic children. SNPs were analysed by RT-PCR. The total serum IgE was measured by chemiluminescence and the serum histamine by ELISA. We used logistic regression analysis to determine OR. Results: Patients carrying the mutant allele for any SNP had more risk to develop higher rhinitis severity or a bigger number of allergic diseases. Haplotype analysis revealed that this effect is synergistic. In patients carrying one or two mutant alleles, serum histamine levels were higher than those of patients carrying only wild alleles. Serum IgE levels were not associated with the presence of mutant alleles. Conclusion: The presence of these SNPs in patients with allergic rhinitis can lead to higher serum histamine, therefore to a higher risk of developing more severe symptoms or more associated allergic diseases, even if the serum IgE remains low. © 2016 SEICAP. |
| Colaborador(es) u otros Autores: | López-Márquez F. Espinosa-Padilla S. Rivera-Guillen M. Gutíerrez-Díaz N. Pérez-Armendáriz L. Rosales-González M. |
| Fecha de publicación : | 2015 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.aller.2016.01.002 |
| Fuente: | Allergologia et Immunopathologia 44(5):433-438 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1970 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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