Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population

Baca V.

Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1926

Título :	Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population
Creador:	Baca V.
Nivel de acceso:	Open access
Palabras clave :	Adolescente Estudios de Casos y Controles Niño Femenino Frecuencia de los Genes Predisposición Genética a la Enfermedad Humanos Masculino México Polimorfismo de Nucleótido Simple - genética Proteína Tirosina Fosfatasa no Receptora Tipo 22 Proteínas Tirosina Fosfatasas Adolescent Case-Control Studies Child Female Gene Frequency Genetic Predisposition to Disease Humans Lupus Erythematosus, Systemic - genetics Male Mexico Polymorphism, Single Nucleotide - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatases - genetics Proteína Tirosina Fosfatasa no Receptora Tipo 22 Polimorfismo Lupus Eritematoso Sistémico Infancia PTPN22 polymorphism systemic lupus erythematosus childhood
Descripción :	Several studies have identified a functional single nucleotide polymorphism 1858C/T in the PTPN22 gene to be associated with several autoimmune diseases. Association studies of this polymorphism with familial and sporadic systemic lupus erythematosus (SLE) have shown some discrepancies. To our knowledge, this is the first study that includes only pediatric-onset SLE patients. We performed a case-control association study in 250 unrelated Mexican patients with childhood-onset SLE consisting of 228 cases with sporadic SLE and 22 cases with familial SLE and 355 healthy controls. We observed a statistically significant difference in the frequency of the PTPN22 1858T allele between SLE patients (3.4%) and healthy controls (1.1%) (P=0.0062, odds ratio (OR) 3.09 (95% confidence interval 1.32-7.21)). The association was also observed when only sporadic cases were analyzed (OR=3.19). Our results support the association of the PTPN22 1858T allele with sporadic childhood-onset SLE in Mexican population.
Colaborador(es) u otros Autores:	Velázquez-Cruz R. Salas-Martínez G. Espinosa-Rosales F. Saldaña-Alvarez Y. Orozco L.
Fecha de publicación :	2006
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1038/sj.gene.6364350
Fuente:	Genes and Immunity 7(8):693 - 695
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1926
Idioma:	eng
Aparece en las colecciones:	Artículos

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