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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1915| Título : | Assessment of oxidative damage induced by acute doses of morphine sulfate in postnatal and adult rat brain |
| Creador: | Calderón Guzmán, David |
| Nivel de acceso: | Open access |
| Palabras clave : | Factores de edad - animales Cerebro - efecto de drogas - Ratas Cerebro - metabolismo - Ratas Relación Dosis-Respuesta a Droga - Ratas glutatión - metabolismo - Ratas Morfina - farmacología - Ratas Morfina - metabolismo - Ratas Morfina - uso terapéutico - Ratas Narcóticos - farmacología - Ratas Estrés oxidativo - efecto de drogas - Ratas Ratas Sprague-Dawley - Ratas Ratas Wistar - Ratas Serotonina - metabolismo - Ratas ATPasa Intercambiadora de Sodio-Potasio - metabolismo - Ratas Age Factors - animals Brain - drug effects - Rats Brain - metabolism - Rats Dose-Response Relationship, Drug - Rats Glutathione - metabolism - Rats Morphine - pharmacology - Rats, Morphine -metabolism - Rats Morphine - therapeutic use - Rats Narcotics - pharmacology - Rats, Oxidative Stress - drug effects - Rats Rats, Sprague-Dawley - Rats Rats, Wistar - Rats Serotonin - metabolism - Rats Sodium-Potassium-Exchanging ATPase -metabolism - Rats Daño cerebral Radicales libres Glutatión Morfina Daño oxidativo Opioides Brain damage Free radicals Glutathione Morphine Oxidative damage Opioids |
| Descripción : | The aim of the present study is to evaluate the oxidative damage in rats of different ages. Weaned rats of 25 g and adults of 300 g were used in groups of 6, a single i.p. dose of morphine sulfate of 3, 6 or 12 mg/kg was administered. All animals were sacrificed to measure GSH and 5-HT levels in brain by liquid chromatography, as well as Na+, K+-ATPase and total ATPase enzymatic activity. 5-HT levels decreased significantly (p<0.05) in adult animals that received 3 and 6 mg morphine. Na+, K+-ATPase activity increased significantly (p<0.05) in all groups of weaned animals. In adult animals, Na+, K+-ATPase and total ATPase partially diminished. GSH levels diminished significantly (p<0.05) both in weaned and in adult groups. The results indicate age-induced changes in cellular regulation and biochemical responses to oxidative stress induced by morphine. |
| Colaborador(es) u otros Autores: | Espitia Vazquez I Osnaya Brizuela N Garcia Alvarez R Barragan Mejia G Hernandez Garcia E Santamaria D De La Rosa De Apreza M Juarez Olguin H |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1007/s11064-006-9053-7 |
| Fuente: | Neurochemical Research 31(4):549 - 554 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1915 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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