Assessment of antioxidant effect of 2,5-dihydroxybenzoic acid and vitamin A in brains of rats with induced hyperoxia

Calderón Guzmán, David

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Título :	Assessment of antioxidant effect of 2,5-dihydroxybenzoic acid and vitamin A in brains of rats with induced hyperoxia
Creador:	Calderón Guzmán, David
Nivel de acceso:	Open access
Palabras clave :	Antioxidantes -ratas Química Encefálica - efectos de drogas - ratas Radicales Libres - Metabolismo - ratas Gentisatos - farmacología - ratas Glutatión - Metabolismo - ratas Hiperoxia - quimioterapia - ratas Hiperoxia - metabolismo - ratas Estrés Oxidativo - Efectos drogas - ratas Estrés oxidativo - fisiología - ratas Ratas Sprague-Dawley Salicilatos - sangre - ratas ATPasa Intercambiadora de Sodio-Potasio - metabolismo - ratas Vitamina A - farmacología - ratas Antioxidants - rats Brain Chemistry - drug effect -rats Free Radicals - metabolism - rats Gentisates - pharmacology - rats Glutathione - metabolism - rats Hyperoxia - drug therapy - rats Hyperoxia - metabolism - rats Oxidative Stress drug effects - rats Oxidative Stress - physiology - rats Rats, Sprague-Dawley Salicylates - blood - rats Sodium-Potassium-Exchanging ATPase - metabolism - rats Vitamin A - pharmacology - rats Ácido acetil salicílico Antioxidantes Cerebro Radicales libres Vitamina A Acetyl salicylic acid Antioxidants Brain Free radicals Vitamin A
Descripción :	The aim of this study was to evaluate the effect of 2,5-dihydroxybenzoic acid, a salicylate derived from Acetyl salicylic acid (ASA) and vitamin A (vit A) on Na+ , K+ ATPase enzyme and GSH levels in brain of rats exposed to hyperoxia (Hyp) as oxidant protocol. Rats were treated as follow: group I (control), group II (Hyp), group III (Hyp, ASA), group IV (vit A), group V (Hyp, vit A), group VI (Hyp, vit A, ASA). Vit A was given 5 days before and during Hyp, aspirin at the end of Hyp. Na+ ,K+ ATPase and total ATPase activity was significantly increased in group V. Levels of GSH showed a significant increase in group III, besides, levels of 2,5-dihydroxybenzoic acid as salicylate in plasma were significantly increased in group II. These results elucidate differences in the biochemical response of animal towards intake of various types of antioxidant substances, with increased GSH and salicylate in hyperoxia.
Colaborador(es) u otros Autores:	Francisca Trujillo Jiménez Ernestina Hernández García Hugo Juárez Olguín
Fecha de publicación :	2007
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1007/s11064-006-9269-6
Fuente:	Neurochemical Research 32(6):1036 - 1040
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1892
Idioma:	eng
Aparece en las colecciones:	Artículos

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