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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1781| Título : | Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry |
| Creador: | Cuevas González J. C. |
| Nivel de acceso: | Open access |
| Palabras clave : | Apoptosis Humanos Inmunohistoquímica Trastornos por Fotosensibilidad - patología Enfermedades Cutáneas Genéticas - patología Apoptosis Humans Immunohistochemistry Photosensitivity Disorders - pathology Skin Diseases, Genetic - pathology Prurigo actínico Apoptosis Cheilitis prurigo actínico Actinic prurigo Apoptosis Cheilitis actinic prurigo |
| Descripción : | Background: Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway). Material and methods: Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. In H&E-stained slides, the diagnosis of AP was corroborated, and 1-µm-thick sections were processed for immunohistochemistry (IHC). A database was constructed with SPSS version 20, Inc., Chicago, IL, USA, and descriptive statistics were analyzed by X2 test and comparison of means. Results: A total of 64 cases were processed, of which 40 (62.5%) were cheilitis AP and 24 (37.5%) were AP in the skin. Of the 40 cheilitis samples, 27 were positive for Bcl-2 and caspase 3 (67.5%), p53 was expressed in 30 (75%). Of the skin lesions, p53 and caspase 3 were expressed in 18 of 24 cases (75%), and 13 were positive for Bcl-2 (54%). Conclusions: We propose that apoptosis is the last step in the type IV subtype a-b hypersensitivity responseactivation of the intrinsic pathway indicates that external factors, such as UV-A and -B are the trigger. © Medicina Oral S. L. C.I.F. |
| Colaborador(es) u otros Autores: | Vega-Memíje M.-E. García-Vázquez F.-J. Rodríguez-Lobato E. Farfán-Morales J.-E. |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.4317/medoral.20765 |
| Fuente: | Medicina Oral, Patologia Oral y Cirugia Bucal 21(1):e53 - e58 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1781 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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