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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1748| Título : | Antioxidant effects of selenium in rat brain and the stimulating role of nitric oxide |
| Creador: | Guzman, David C |
| Nivel de acceso: | Open access |
| Palabras clave : | Antioxidantes - farmacología Encéfalo - enzimología Oxido nítrico - fisiología Selenio - Farmacología ATPasa Intercambiadora de Sodio-Potasio Antioxidants - pharmacology Brain - enzymology Nitric Oxide - physiology Selenium - pharmacology Sodium-Potassium-Exchanging ATPase - metabolism Selenio Regiones del cerebro Peroxidación de lípido Na K ATPasa Selenium Brain regions Lipid peroxidation Na K ATPase |
| Descripción : | OBJECTIVE: To evaluate the antioxidant effect of selenium on Na+, K(+)-ATPase in rat brain in the presence of nitric oxide. METHODS: Male Wistar rats (70 g) were treated as follows: group 1 received 1 microg of i.p. sodium nitroprus-side per kg (SNP), group 2 received 5 microg sodium selenite during 20 days, group 3 received sodium selenite 5 microg + SNP 1 microg and the control group received vehicle 50 microl (0.9% NaCl), same period and route. At the end of treatment, animals were sacrificed and their brain dissected into cortex, hemispheres, cerebellum and brain stem in order to determine lipid peroxidation (TBARS), Na+, K+ ATPase and total ATPase in each section. Blood hemoglobin concentration (Hb) and prostate weight were also assessed. RESULTS: A significant increase of Hb in blood and of proteins in cortex and hemisphere was detected, but TBARS values fell due to the effect of sodium selenite in all examined regions, except for cerebellum. ATPase activity declined in all groups and regions with and without NTP. We conclude that diet supplementary selenium to inhibit NO generation can be a useful treatment in chronic inflammatory diseases. |
| Colaborador(es) u otros Autores: | Ruiz NL Mejía GB García EH Vázquez IR Del Angel DS Ramírez AM Juárez Olguín H |
| Fecha de publicación : | 2003 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1080/1028415031000104181 |
| Fuente: | Nutritional Neuroscience 6(3):177 - 182 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1748 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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