Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1726| Título : | Antioxidant capacity of "mexican arnica" heterotheca inuloides cass natural products and some derivatives: Their anti-inflammatory evaluation and effect on C. elegans life span |
| Creador: | Rodríguez Chávez, José Luis |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Antiinflamatorios - química Antiinflamatorios - aislamiento & purificación Antiinflamatorios - farmacología Antioxidantes - química Antioxidantes - metabolismo Asteraceae - química Asteraceae - metabolismo Productos Biológicos - química Productos Biológicos - aislamiento & purificación Productos Biológicos - farmacología Caenorhabditis elegans - fisiología Depuradores de Radicales Libres - química Peroxidación de Lípido - efectos de drogas Longevidad - efectos de drogas Extractos Vegetales - química Especies Reactivas de Oxígeno - química Especies Reactivas de Oxígeno - metabolismo Superóxidos - química Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antioxidants - chemistry Antioxidants - metabolism Asteraceae - chemistry Asteraceae - metabolism Biological Products - chemistry Biological Products - isolation & purification Biological Products - pharmacology Caenorhabditis elegans - physiology Free Radical Scavengers - chemistry Lipid Peroxidation - drug effects Longevity - drug effects Plant Extracts - chemistry Reactive Oxygen Species - chemistry Reactive Oxygen Species - metabolism Superoxides - chemistry- Antiinflamatorios Antioxidantes Asteraceae Caenorhabditis elegans Anti-Inflammatory Agents Antioxidants Asteraceae Caenorhabditis elegans |
| Descripción : | It has been suggested that the accumulation of biomolecular damage caused by reactive oxygen species (ROS) contributes to aging. The antioxidant activity is related to the ability of certain compounds to protect against the potentially harmful effect of processes or reactions involving ROS. This ability is associated with the termination of free radical propagation in biological systems. From Heterotheca inuloides various compounds which have shown to possess antioxidant capacity and scavenging ROS. The aim of this study was to determine the antioxidant capacity of additional natural components isolated from H. inuloides and some semisynthetic derivatives, their anti-inflammatory activity and the effect on Caenorhabditis elegans nematode life span. Compounds showed ability to inhibit various biological processes such as lipid peroxidation, scavenge nonbiological important oxidants such as 1O2, OH, H2O2, and HOCl and scavenge non biological stable free radicals (DPPH). Some cadinane type compounds showed possess antioxidant, ROS scavenging capacity, anti-inflammatory activity, and effect on the C. elegans life span. Flavonoid type compounds increased the life of the nematode and quercetin was identified as the compound with the greatest activity. The modification of chemical structure led to a change in the antioxidant capacity, the anti-inflammatory activity, and the survival of the worm. © 2015 José Luis RodrÃguez-Chávez et al. |
| Colaborador(es) u otros Autores: | Coballase-Urrutia E Nieto-Camacho A Delgado-Lamas G. |
| Fecha de publicación : | 2015 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1155/2015/843237 |
| Fuente: | Oxidative Medicine and Cellular Longevity 2015():1-11 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1726 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.