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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1626| Título : | Anti-cardiolipin, anti-cardiolipin plus bovine, or human beta(2)glycoprotein-I and anti-human beta(2)glycoprotein-I antibodies in a healthy infant population |
| Creador: | Cabiedes J., |
| Nivel de acceso: | Open access |
| Palabras clave : | Adulto Animales Anticuerpos Anticardiolipina - sangre Autoanticuerpos - sangre Autoanticuerpos - inmunología Bovinos Niño Preescolar Ensayo de Inmunoadsorción Enzimática Glicoproteínas - inmunología Humanos Inmunoglobulina A - sangre Inmunoglobulina A - inmunología Inmunoglobulina G - sangre Inmunoglobulina G - inmunología Inmunoglobulina M - sangre Inmunoglobulina M - inmunología Lactante Masculino México Valores de Referencia beta 2 Glicoproteína I Adult Animals Antibodies, Anticardiolipin - blood Autoantibodies - blood Autoantibodies - immunology Cattle Child Child, Preschool Enzyme-Linked Immunosorbent Assay Glycoproteins - immunology Humans Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M - blood Immunoglobulin M - immunology Infant Male Mexico Reference Values beta 2-Glycoprotein I True anticardiolipin antibodies Anti-β2GP-I antibodies ELISA Healthy Mexican children |
| Descripción : | Background. Pathogenic antiphospholipid antibodies studies are usually conducted on populations of adults. Studies involving normal children are scant. Methods. Antibody reactivity against CL alone (true aCL), CL-complexed to bovine β2GP-I (aCL-bovine β2GP-I), or human (aCL-human β2GP-I) β2GP-I, or to phospholipid-free human β2GP-I (anti-human β2GP-I) was determined by ELISA in serum samples from 360 Mexican children ranging from 1 month through 8 years of age. Results. Statistical analysis of variance and rankings of Kruskal-Wallis demonstrated no significant difference in all tested antibody activities between ages and genders of the study population. Values are presented as a percentile distribution included between 5 and 99, corresponding to the percentages of the studied population. Normal arbitrary units (AU) for IgG, IgA, and IgM true aCL that correspond to the 95 and 99 percentiles are as follows: 2.15 and 3.5; 2.35 and 5.0, and 3.15 and 4.5, respectively. IgG, IgA, and IgM aCL-bovine β2GP-I activities are 2.6 and 5.0, 3.0 and 5.0, and 2.7 and 6.0 AU, respectively, while IgG activities of aCL-bovine and human β2GP-I are 1.45 and 1.80, respectively. Normal values for IgG anti-human β2GP-I are 1.85 AU. Conclusions. While elevated serum levels of antibodies to CL and/or β2GP-I have been associated with thrombotic and hematologic manifestations, the majority of reports deal with adult populations. We report the cut-off values (in AU, international PL units, and international units for β2GP-I) of the specific serologic response of true aCL, aCL-bovine β2GP-I, aCL-human β2GP-I, and anti-human β2GP-I in healthy Mexican children. © 2002 IMSS. Published by Elsevier Science Inc. |
| Colaborador(es) u otros Autores: | Trejo-Hernández J. Loredo-Abdala A. Castilla-Serna L. López-Mendoza A.T. Cordero-Esperón H.A. Huerta M.T. Cabral A.R. Alarcón-Segovia D. |
| Fecha de publicación : | 2002 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/S0188-4409(01)00359-9 |
| Fuente: | Archives of Medical Research 33(2):175 - 179 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1626 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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