1. Instituto Nacional de Pediatría
2. INP
3. Artículos

Título :	Antihelmínticos como factor de riesgo en la obstrucción intestinal por Ascaris lumbricoides en niños Anthelmintics as a risk factor in intestinal obstruction by Ascaris lumbricoides in children
Creador:	Vásquez Tsuji O.,
Nivel de acceso:	Open access
Palabras clave :	Adolescente Albendazol - Efectos adversos Albendazol - uso terapéutico Animales Antihelmínticos - Efectos adversos Antihelmínticos - uso terapéutico Ascariasis - complicaciones Ascariasis - tratamiento farmacológico Ascaris lumbricoides Estudios de Casos y Controles Distribución de Chi-Cuadrado Niño Preescolar Femenino Humanos Lactante Obstrucción Intestinal - inducido químicamente Obstrucción Intestinal - parasitología Modelos Logísticos Masculino Mebendazol - Efectos adversos Mebendazol - uso terapéutico Oportunidad Relativa Estudios Retrospectivos Factores de Riesgo Adolescent Albendazole - adverse effects Albendazole - therapeutic use Animals Anthelmintics - adverse effects Anthelmintics - therapeutic use Ascariasis - complications Ascariasis - drug therapy Ascaris lumbricoides Case-Control Studies Chi-Square Distribution Child Child, Preschool Female Humans Infant Intestinal Obstruction - chemically induced Intestinal Obstruction - parasitology Logistic Models Male Mebendazole - adverse effects Mebendazole - therapeutic use Odds Ratio Retrospective Studies Risk Factors Vermifugos Factores de Riesgo Obstrucción Intestinal Ascariasis Anthelmintics Risk Factors Intestinal Obstruction Ascariasis
Descripción :	In a retrospective study the authors analyzed the clinical records of 199 children ages one month to 16 years hospitalized, with the diagnosis of intestinal ascariasis, in the Instituto Nacional de Pediatria of Mexico from 1984 to 1999. The purpose of the study was to evaluate the use of anthelmintics drugs as a risk factor of intestinal obstruction by A. lumbricoides. Two groups were made for the study: Group A (n = 66) of children who presented intestinal obstruction, Group B (n = 133) children with no complications. A comparative analysis of clinical data of both groups was made by means of chi square with Yates correction and a stratified analysis by means of chi square. Possible confusing elements were overcrowding, age and the use of antiparasitic drugs. The calculus of risk factors for intestinal obstruction by A. lumbricoides was done by means of contingency tables of 2 x 2 and odds ratio with an IC of 95%. The significant risk factors were included in a model of logistics regression with an impact variable consting in the presence or absence of intestinal obstruction in order to establish a multivariate model of predictive risk at level of significance of p < 0.05. Twenty-seven patients (40.90%) in group A (n = 66) were given anthelmintics medications prior to the intestinal obstruction: mebendazol, 14 (51-85%); two, albedazol (7.4%); eight, a non-specified anthelmintic (29.6%). In addition, an anthelmintic medication without a specified time of ingestion: two with mebendazol and one with piperazine (11.3%). In the case of mebendazol, the drug most frequently associated with intestinal obstruction, seven patients received it on the same day of the obstruction; five patients received it between one and seven days prior to the obstruction; two received it seven days prior to the complication. In the control group, only 7% had taken the anthelmintic one to seven days before the diagnosis of uncomplicated intestinal ascariasis diagnosis was made. With the step by step (Backward) logistic regression conditioned by the treatment variable with an anthelmintic, an X2 = 38.15 gl, p < 0.000 was obtained for which reason it was considered by A. lumbricoides. Of the probable risk factors analyzed in this study, the only one capable of influencing and predicting the presentation of intestinal obstruction by A. lumbricoides in children, was the prior anthelmintic treatment particularly with mebendazol.
Colaborador(es) u otros Autores:	Gutiérrez Castrellón P. Yamazaki Nakashimada M.A. Arredondo Suárez J.C. Campos Riveral T. Martínez Barbosa I.
Fecha de publicación :	2000
Tipo de publicación:	Artículo
Formato:	pdf
Fuente:	Boletin Chileno de Parasitologia 55(1-2):3 - 7
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/1593
Idioma:	spa
Aparece en las colecciones:	Artículos

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.